Bone Metastasis is a common complication of malignancy. It causes considerable morbidity with pain, impaired mobility, hypercalcemia, pathologic fractures, spinal cord compression & bone marrow infiltration.
Bisphosphonates are the current standard of care for preventing skeletal complications associated with bone metastasis. How Pamidronate works?
• It prevents recruitment of osteoclast precursors
• Prevents maturation of osteoclasts
• Prevents binding of mature osteoclasts to bone surface
• Induces apoptosis (programmed cell death)
Ref: [14] J Clin Oncol 21:4042-4057. © 2003 by American Society of Clinical Oncology.
[15] M. Kraj et al. Long term safety and efficacy of Zoledronic acid as compared with Pamidronate.
Thrombocytopenia may compromise cancer treatment, causing chemotherapy dose reductions, schedule alterations, or the need for platelet transfusions.
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