Sustained occupation of pituitary GnRH receptors by Leuprorelin results in desensitization and/or downregulation of receptors in the anterior pituitary, thereby suppressing gonadotrophin release and reducing testosterone release by the human testes to castrate levels.
It act directly on cell growth in human prostatic cancer cells, behaving like a negative growth factor. [12]
It offers maximum androgen blockade in combination with Nonsteroidal Anti Androgen (NSAA) as compared to NSAA Monotherapy having the highest estimated quality adjusted survival. [13]
Ref: [12] LEUPRORELIN ACETATE IN PROSTATE CANCER: A EUROPEAN UPDATE – J. UROL. UROGYNÄKOL. Sonderheft 3/2002
[13] Guidelines on Prostate Cancer – European Association of Urology 2015 – Pg 60
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